Entries by psomagen

How can DNA sequencing be applied to the medical field?

What is genome sequencing? If you could study the map of your patients and foresee the pitfalls and obstacles – if you could navigate them and make your patients’ life easier and safer – would you? Genome sequencing can break open the cell membranes that exist in a sample of your patient’s blood or saliva […]

Clinical Whole Exome Sequencing

What is Whole Exome Sequencing? If you’re trying to find a cause for your patients’ symptoms, clinical whole exome sequencing (WES) can reveal the origins of a genetic trait or illness. How does it work? An exon, or “expressed region,” is the coding part of DNA and ultimately gets translated to protein. Using saliva, blood, […]

Scholarship Winner

After careful review of all scholarship submissions, we have chosen a winner! Congratulations to Tianna Chemello from Northern Arizona University! If you or somebody you know would like to make a submission for next semester visit our Scholarship page.

How is NGS Different from Sanger Sequencing?

Introduction Sequencing DNA involves biochemical processes to ascertain the order (sequence) of nucleotides of DNA strands. Maxam-Gilbert and Sanger methods were developed over 40 years ago, but the Sanger method soon dominated the DNA sequencing arena. With this method, DNA is repeatedly copied resulting in DNA fragments of varying lengths. The ends of each fragment […]

Macrogen Corp.’s Clinical NGS Laboratory Receives CAP Accreditation – Press Release

ROCKVILLE, MD – Macrogen Corp. announces that its Clinical Lab that provides clinical NGS services has been awarded accreditation by the Accreditation Committee of the College of American Pathologists (CAP) based on results of a recent on-site inspection as part of the CAP’s Accreditation Programs. “Macrogen demonstrates leadership, innovation, and a passionate commitment to standards […]

Race and Predisposition to Disease

Introduction Interdisciplinary efforts over several decades have provided intriguing information regarding the factors that contribute to racial differences in health status and outcomes. Even with this information on hand, challenges remain regarding improved characterization of these various biological and environmental factors. Advances in genomic studies have provided some of the valuable tools and data needed […]

Next Generation Sequencing Could Dramatically Impact Life Expectancy

Introduction A Centers for Disease Control website provides a definition for life expectancy as “the average number of years that a hypothetical group of infants would live at each attained age if the group was subject, throughout its lifetime, to the age-specific death rates prevailing for the actual population in a given year” (1). It […]

Chromatin Immunoprecipitation-sequencing (ChIP-seq)

Chromatin Immunoprecipitation assays have the ability to capture an image of specific protein to DNA interactions that are occurring in a system and process these interactions using quantitative polymerase chain reaction (qPCR), ChIP-chip, or next generation sequencing (NGS). When paired with next generation sequencing specifically, ChIP-seq is a powerful way to identify genome-wide DNA binding […]

Sequencing Data to Develop Recombinant Vaccines

Introduction Eradication and prevention of infectious diseases are achieved most often via vaccination. The common or traditional vaccines are made using the actual pathogen material, such as modified live or killed (inactivated) viruses. The use of these types of vaccines is sometimes associated with serious side effects. For some infectious agents, it is often difficult […]