How is NGS Different from Sanger Sequencing?

Introduction Sequencing DNA involves biochemical processes to ascertain the order (sequence) of nucleotides of DNA strands. Maxam-Gilbert and Sanger methods were developed over 40 years ago, but the Sanger method soon dominated the DNA sequencing arena. With this method, DNA is repeatedly copied resulting in DNA fragments of varying lengths. The ends of each fragment […]

Role of Next-Generation Sequencing in Pancreatic Cancer Management

Introduction Pancreatic cancer (PC) is considered one of the most fatal cancers in the U.S. and other developed countries. The best outcomes and survival rates after treatment are only possible with early detection and treatment before the onset of symptoms. There is a great need to uncover ways to detect PC early to achieve better […]

Advances in Microbiome Diagnostics

Introduction The organisms that are a part of our normal biology are essential for our survival and well-being. The genetic material of these organisms collectively makes up the human microbiome. However, there are many scientists that use the term microbiome interchangeably with microbiota (the actual normal microorganism in a particular environment, such as the human […]

Circulating Tumor DNA Methodologies

Introduction The analysis of cell-free DNA or liquid biopsy is emerging as a noninvasive clinical tool to aid in achieving accurate diagnoses. It is also a valuable research tool to determine biomarkers of disease, identify drug targets, and ascertain the factors responsible for drug resistance. Circulating tumor DNA refers to cell-free DNA that are fragments […]

Next-Generation Sequencing: Popular Applications in Clinical Medicine

Introduction and Brief overview of NGS An important technological advance in the practice of diagnostic and clinical medicine is next-generation sequencing (NGS). This technology is rapidly transforming clinical practice by providing a means to obtain both diagnostic and prognostic data with the same data. This transformation is made possible because of the cost-effective and rapid […]

The Top 5 Next Generation Sequencing (NGS) Forums and Communities

Next Generation Sequencing (NGS) has seen massive growth as the demand for low-cost sequencing has exploded. Information on NGS, though, is highly technical, and it’s important to go to the right sources to discuss the varying technologies in the field. These are the top 5 Next Generation Sequencing forums in 2016:   SEQanswers SEQanswers is […]

Macrogen Corp Announced as precision FDA Participating Provider

Macrogen Corp., one of the leading providers of next-generation sequencing services, has been announced as a participating provider in precisionFDA. The precisionFDA web platform is part of President Obama’s vision with his Precision Medical Initiative announced last year. The administration’s goal is to move away from a “one-size-fits-all” approach to medicine and move towards a […]

The Top Five Genome Conferences In The World

The emergence and growth of whole genome sequencing technologies, and the resulting immense database generated, requires that scientists and medical professionals learn more about the powerful tools available to them. These tools give scientists the ability to interpret and apply the information and are becoming increasingly available. Genomic technologies have bolstered the power of personalized […]

Macrogen Provides Patient-Specific Interpretation for the Launch of New Clinical Next-Generation Sequencing Panels

Macrogen has recently partnered with N-of-One, a leader in clinical interpretation, with the goal of delivering high-level clinical interpretation for its newly launched clinical next-generation sequencing panels. N-of-One enables laboratories to save time and money while scaling their molecular diagnostics programs. It also provides therapeutic options to client organizations for thousands of cancer patient cases. […]

Macrogen Completes Merger of US Affiliates to Become Macrogen Corp.

Merger will help Macrogen Corp. eliminate redundant R&D and business costs and provide a unified clinical diagnosis service   Recently, biotechnology and precision medicine firm Macrogen merged a trio of its U.S. based affiliates. The move will effectively align the affiliates behind the company’s core mission: Precision medical research and clinical diagnosis. Now, Macrogen Corporation […]