Race and Predisposition to Disease

Introduction Interdisciplinary efforts over several decades have provided intriguing information regarding the factors that contribute to racial differences in health status and outcomes. Even with this information on hand, challenges remain regarding improved characterization of these various biological and environmental factors. Advances in genomic studies have provided some of the valuable tools and data needed […]

Next Generation Sequencing Could Dramatically Impact Life Expectancy

Introduction A Centers for Disease Control website provides a definition for life expectancy as “the average number of years that a hypothetical group of infants would live at each attained age if the group was subject, throughout its lifetime, to the age-specific death rates prevailing for the actual population in a given year” (1). It […]

Chromatin Immunoprecipitation-sequencing (ChIP-seq)

Chromatin Immunoprecipitation assays have the ability to capture an image of specific protein to DNA interactions that are occurring in a system and process these interactions using quantitative polymerase chain reaction (qPCR), ChIP-chip, or next generation sequencing (NGS). When paired with next generation sequencing specifically, ChIP-seq is a powerful way to identify genome-wide DNA binding […]

Role of Next-Generation Sequencing in Pancreatic Cancer Management

Introduction Pancreatic cancer (PC) is considered one of the most fatal cancers in the U.S. and other developed countries. The best outcomes and survival rates after treatment are only possible with early detection and treatment before the onset of symptoms. There is a great need to uncover ways to detect PC early to achieve better […]

Advances in Microbiome Diagnostics

Introduction The organisms that are a part of our normal biology are essential for our survival and well-being. The genetic material of these organisms collectively makes up the human microbiome. However, there are many scientists that use the term microbiome interchangeably with microbiota (the actual normal microorganism in a particular environment, such as the human […]

HLA and Pharmacogenetics

Introduction For years, the unpredictability of drug reactions has served as an underlying uncertainty in the safety of medications. This is because many of these reactions are specific to certain individuals and populations and under specific circumstances with an unknown basis. Adverse drug reactions can be very medically devastating, leading to severe consequences including death. […]

The Promise and Security Risks of using Cloud-Based Informatics Solutions for Human Genomic Data Analysis

Introduction The ability for medical and research scientists around the globe to share data has enhanced the progress of medical discovery and healthcare delivery. Instant access to information via cloud-based technology by researchers and healthcare providers allows more time spent acting on and processing data. However, large bodies of data (aka “big data”) generated through […]

The Top 5 Next Generation Sequencing (NGS) Forums and Communities

Next Generation Sequencing (NGS) has seen massive growth as the demand for low-cost sequencing has exploded. Information on NGS, though, is highly technical, and it’s important to go to the right sources to discuss the varying technologies in the field. These are the top 5 Next Generation Sequencing forums in 2016:   SEQanswers SEQanswers is […]

Macrogen Corp Announced as precision FDA Participating Provider

Macrogen Corp., one of the leading providers of next-generation sequencing services, has been announced as a participating provider in precisionFDA. The precisionFDA web platform is part of President Obama’s vision with his Precision Medical Initiative announced last year. The administration’s goal is to move away from a “one-size-fits-all” approach to medicine and move towards a […]

The Top Five Genome Conferences In The World

The emergence and growth of whole genome sequencing technologies, and the resulting immense database generated, requires that scientists and medical professionals learn more about the powerful tools available to them. These tools give scientists the ability to interpret and apply the information and are becoming increasingly available. Genomic technologies have bolstered the power of personalized […]