Managing High-Throughput DNA Sequencing Data

Introduction The newest sequencing technologies are providing new insights into disease etiology, individual susceptibilities, keys to drug discovery, and more. However, there are many questions and challenges regarding how to understand the meaning and applicability of the newfound wealth of data. As new data is generated at record rates, scientists are working diligently on the […]

Macrogen Deploys Advanced Data Processors for Faster Analysis of Large-Scale Genomic and Sequencing Data

Macrogen recently partnered with Edico Genome to reinforce its Bio-IT infrastructure with new DRAGEN processors. By deploying several DRAGEN Bio-IT Processors, which are designed and manufactured by Edico Genome, Macrogen will be able to provide faster processing and analysis of high-throughput NGS data. Accurate DNA sequencing and genomic analysis is reliant on advanced technology. To […]

How the Genome Asia 100K Initiative is Impacting Disease Research

The Genome Asia 100K Initiative announcement made big waves earlier this year as it is the first significant pan-Asian endeavor with the goal of creating a comprehensive genomic database. The initiative is similar to the 100K Genome Project in the United Kingdom and the US Precision Medicine Initiative. The Genome Asia 100K initiative is led […]

Discovering Drug Resistance Using DNA Sequencing

What is Drug Resistance? The World Health Organization (WHO) defines drug resistance (also called antimicrobial resistance) as the change that occurs in microorganisms that renders medications ineffective. There are other types of drug resistance, such as cancer cell resistance to chemotherapeutic agents. This discussion, however, will focus on antimicrobial drug resistance. As antimicrobial drugs become […]

Macrogen and Silicon Biosystems Menarini to Co-Develop CLIA-Certified Genomic Cancer Assays

Collaboration Aims to Integrate Digital Sorting with Next Generation Sequencing (NGS) of Formalin-Fixed Paraffin-Embedded Biopsies and Fine-Needle Aspiration Samples SAN DIEGO and SEOUL, South Korea, Feb. 12, 2016 /PRNewswire/ — Silicon Biosys­tems Menarini and Macrogen, Inc. today announced they will form a partnership to provide clinical assays and innovative procedures for precision medicine in cancer. […]

DNA Sequencing: The Backbone of Personalized Medicine

Concept of Personalized Medical Care As a society, we have been accustomed to the concept of a “one-size-fits-all” approach to healthcare. However, this has not been ideal for many people and limits the success of medical management. There are instances where there is some level of tailoring to the individual, but not to the extent […]

Next-Generation Sequencing Revolutionizes Drug Discovery and Development

Next-Generation Sequencing (NGS) Overview Next-generation sequencing is a massive parallel sequencing technology. Genomic DNA is extracted, fragmented, and linked to adapters and primers for the amplification reaction (PCR) to generate a library. DNA fragments in the library are simultaneously sequenced. This provides a massive set of sequence data in a matter of days. The data […]

Role of Epigenetic Changes in the Etiology of Human Diseases

Introduction The field of epigenetics is ever-growing and considered to be a relatively new branch of genetic research. However, the concept dates back to the 1940s when it was understood as a mechanism that involved gene and gene-product interactions responsible for phenotypic expression1. Epigenetics is now understood as stable, heritable changes in gene expression that […]

How Transposons are Changing the Sequencing Industry

Introduction Mobile DNA segments that can change position, transpose, are transposons (or transposable elements). These “jumping genes” discovered by Barbara McClintock 70 years ago exist in species of all kingdoms, from bacteria to humans. Transposons make up large portions of a species’ genome and have key biological functions. In humans, transposons make up nearly 50% […]

The Race for the $1,000 Genome: The Increasing Speed and Accuracy of DNA Sequencing

Science fiction fans remember the Star Trek tricorders that rapidly rendered a diagnosis, or the database that could provide the entire past and present information (even the molecular details) of a scanned planet. The state of science, as we live it today, reflects the path to bring many of these concepts into fruition. Although discovering […]