Correlation of PAL score (y-axis) with age (x-axis) by genotype for the top SNPs located in NEDD9.

iGenomX Next Generation Genotyping Paves Way for Mass-Scale Alzheimer’s Research

iGenomX, in collaboration with MindCrowd, applied their RIPTIDETM library preparation technology to an Alzheimer’s research study cohort. MindCrowd utilizes online-based Paired-Associates Learning (PAL) task programs for Alzheimer’s research that allows for web-based memory assessment of more than 1,000,000 participants. Participants from this assessment phase were criteria selected for DNA samples and genotyped using RIPTIDETM High Throughout Rapid Library Prep (HT-RLP). This method enabled iGenomX researchers to produce 10x the data of standard next-generation genotyping at a fraction of the cost. The combined advantages of internet-based phenotype recruitment and at-home sample collection with RIPTIDETM technology enabled a mass-scale population study to acquire both known and novel genetic associations with Alzheimer’s disease.

For this study, Psomagen sequenced 96 samples per lane on an Illumina NovaSeq S4 flow cell.

 

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