Bioinformatics Services

About Bioinformatics

Bioinformatics combines computer science, statistics, mathematics, and engineering to study and process biological data. This field is primarily concerned with the analysis of genetic information contained in nucleic acids and data from protein sequences.

Geneticists have already gained countless new insights into the structure and function of many organisms, thanks to the mass amounts of information yielded by this method of sequencing. Bioinformatics is able to yield so much information because it uses elements of computer science, engineering, biotechnology, and molecular biology to analyze and manage large data sets.

The Aims of Bioinformatics

Bioinformatics is the branch of biology that aims to efficiently organize vast amounts of biological data, to develop tools for accomplishing that purpose, and to draw meaningful conclusions from those data sets.  This sequencing method can be used to make sense of the genetic information of any living thing, from a single-celled organism to an intricate ecosystem. 

Recent technological developments have caused a sudden surge in the use of bioinformatics, making it easier to sequence the human genome (consisting of about 3 billion base pairs) than it ever has been before.

Our Bioinformatics Sequencing Services

At Psomagen, we offer a range of sequencing analysis services, using the sequences of DNA, RNA, or a peptide to understand the unique features of your DNA. Our highly experienced Bioinformatics specialists are dedicated to offering these services with the very best quality and accuracy.  Our analytical capabilities using extensive next-generation sequencing (NGS) data include but are not limited to the following:

  • High-quality control and assurances for data and statistics
  • Discovery of SNPs, InDels, and structural variations including CNVs
  • Annotation of variants
  • Association analysis
  • Gene expression analysis
  • Alternative splicing transcripts identification
  • Peak analysis (ChiP-Seq)

Additional Bioinformatics Solutions

Whole Genome Sequencing (WGS)

  • De novo sequencing
    • Basic: Consensus sequence assembled into contigs
    • Advanced: Gene prediction and annotation
  • Resequencing
    • Basic: Mapping to the current reference genome, analysis of mapping statistics, SNPs and InDels calling, variant list in VCF or Excel formats
    • Advanced: A variety of options for mapping algorithms, variant detection algorithms, annotations, mapping to public databases
  • RNA
    • De Novo Sequencing
      • Basic: De novo assembly statistics, gene expression profile
      • Advanced: Blastnt or blastnr, differentially expressed genes (DEGs), gene annotations, and ontology analysis
    • Resequencing
      • Basic: Mapping statistics, gene expression profile, SNPs and InDels calling by mapping to reference genome (human, mouse, rat), novel transcripts, alternatively spliced transcripts, fusion gene (human, mouse, rat)
      • Advanced: Customized analysis, differentially expressed genes (DEGs), gene ontology analysis
  • Exome
    • Basic: Variant calling (SNPs/InDels) and annotation
    • Advanced: CNV (Copy Number Variation), various variant calling pipeline, cancer analysis/family analysis/population analysis
  • Epigenome
    • Basic: Global methylation profiles, specific methylation profiles (CpG islands and differentially methylation regions (DMRs))
    • Advanced: DMR-associated genes, gene set analysis, comparative analysis
  • Metagenomics
    • Basic (Amplicon): Community diversity analysis (OTU), probiotics analysis
    • Basic (Shotgun): Assembly, gene prediction and annotation, taxonomy analysis
    • Advanced (Amplicon): Phylogenic tree, hierarchical taxonomy graph, heatmap, PCA biplot

Call us for more information about additional bioinformatics solutions for targeted sequencing, small RNA sequencing, long-read sequencing, and more.

Applications of Bioinformatics

In the world today, bioinformatics is used to understand the genetic factors that underlie disease, the desirable genetic properties of agricultural species, the distinguishing genetic traits among populations,  and so much more. Bioinformatics is being used increasingly in genetic sequencing, medicinal discovery, and even gene expression studies. 

More specifically, this tool is useful for finding links between disease and genetic sequences. Therefore, pharmacogeneticists can use this information to alter drugs, vaccines, and medical treatments and tailor them to the DNA of the patients receiving them.

Why Choose Psomagen?

Psomagen’s sophisticated processes are quality assured in order to bring you the utmost accurate data in the timeliest manner, all at a competitive cost with a flexible and customizable workflow. You can obtain more information regarding our processes and bioinformatics services by contacting us directly and speaking with a representative. 

Contact us about our bioinformatics services today!

Inquire About Our Bioinformatics Services