While WGS is the more popular option, both WGS and WES have unique advantages. When deciding which sequencing option to use, it’s important to understand the difference between both.
WES focuses on the express regions of the genome and uses enrichment strategies that prove to help target specific areas. Since WES only worked with expressed areas of the genome and targeted sequencing and not the whole genome, it is more cost-effective than WGS. With whole-exome sequencing or targeted sequencing, you get deeper coverage and more information — up to 5,000 times compared to whole-genome sequencing. Clinical whole-exome sequencing is a routine option for diagnostics tests to help provide deeper insights into your personal health.
WGS focuses on the whole genome, specifically the exons and introns( the expressed and intervening sequences). Where WES looks at specific areas of interest, WGS checks the whole genome for sequence alignment. And, where WGS profiles the whole genome, it is usually more expensive than WES.