Research

RNA Sequencing Services

Psomagen offers high-quality RNA sequencing services, also called transcriptome sequencing. Our state-of-the-art automated sequencing reduces the turnaround time for researchers at low prices, yet retains the highest levels of quality. Our RNA / transcriptome sequencing methods are reliable, fast, and cost-effective. We also provide bioinformatics services regarding differentially expressed genes, fusion genes, post-translation modification of specific mRNA transcripts, and more. We offer RNA / transcriptome sequencing services for researchers in the United States and around the globe.

What Is RNA / Transcriptome Sequencing?

A transcriptome is a collection of all the transcripts present in a given cell. The sequence of an RNA mirrors the sequence of the DNA from which it was transcribed. Consequently, by analyzing the entire collection of RNAs or transcriptomes in a cell, researchers can determine when and where each gene is turned on or off in the cells and tissues of an organism.

RNA sequencing can give researchers more visibility into previously undetected changes that can occur in certain states of diseases. Researchers can also see more details about how a transcriptome reacts to certain therapeutics, environmental situations, or other conditions.

With RNA sequencing, researchers can discover more about a transcriptome in just one assessment, including new and existing qualities. RNA sequencing can detect alternative gene spliced transcripts, gene fusion, mutations and variants, post-transcriptional modifications, and other gene expressions.

As DNA sequencing technology advances, RNA / transcriptome sequencing has become more cost-effective and more widely available. This increase in usage has made RNA sequencing an excellent tool for RNA editing, RNA profiling, and allele-specific expression.

Psomagen Inc. RNA / transcriptome sequencing services include the following:

  • Transcript isoform discovery and their validation
  • Coding and annotation with SNPs
  • Profiling and characterization junctions
  • Quantitative determination and identification of regulatory transcripts

Types of RNA / Transcriptome Sequencing

Researchers utilize many different methods of RNA / transcriptome sequencing to identify existing and novel types of gene expression. At Psomagen Inc., we use only the most advanced industry-standard methods, including the following:

  • mRNA Sequencing: This type of RNA sequencing is one of most popular methods for analyzing disease states and biological processes in the study of transcriptomes. This method is extremely in-depth, allowing researchers to find new genes that were previously imperceptible.
  • Small RNA Sequencing: This type of sequencing targets and isolates small RNA, including microRNA, to discover how noncoding RNA affects different types of gene expressions.
  • Whole RNA Sequencing: Whole RNA sequencing is a comprehensive method that aims to accurately measure the amount of genes and transcripts in the transcriptome. It identifies existing and novel coding and noncoding RNA.
  • Targeted RNA Sequencing: This sequencing method focuses on two different types of targeted transcriptome assessment: targeted enrichment and targeted amplicon.
  • RNA Exome Capture Sequencing: This method of RNA sequencing identifies different types of the RNA exome by examining specific regions of RNA coding.
  • Single-Cell RNA Sequencing: This type of RNA sequencing studies individual cells, specifically the transcriptomes and genomes. This allows researchers to examine the small complexities of each region of a transcriptome.
researcher doing lab work

Benefits of RNA / Transcriptome Sequencing

Because this form of sequencing does not require prior knowledge about the transcript, it can identify information that might be overlooked by other methods. Some of its benefits include:

  • Captures both previously known and novel transcriptome features
  • Provides close, accurate studies of a variety of gene expression
  • Offers accurate results often at a lower price point per sample

RNA sequencing is precise in measuring transcripts and identifying complexities. It can more accurately determine gene expressions than many other methods of arrays.

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