What Is Whole-Genome Sequencing?
Whole-genome sequencing (WGS) is the process of determining the order of bases (adenine, guanine, thymine, or cytosine) of all DNA in any living organism. WGS is the preferred method to identify chromosome abnormalities through copy number variations and other structural variations.
This can be achieved from a single sample using a single, massively parallel process known as next-generation sequencing (NGS). It is often used in discovery and exploratory studies, as well as in clinical applications.
Why Is Studying Whole Genome Sequencing Important?
The ability to characterize an entire organism’s genome offers possibilities in all fields of science. WGS aids research in infectious disease, microbiology, immunology, inherited disease, oncology, reproductive health, forensics, and more.
It can be used to identify new disease targets, diagnose inherited disorders, and help predict who will benefit from a given therapy.
Unsure what you're hoping to find? WGS gives you insight into genome-wide changes, offering the broadest range of coverage.
What Can You Do?
Process Both RUO and Clinical Samples
Access both research-use-only and CAP/CLIA services.
Get Analytics & Bioinformatics
Maximize insights with our dedicated bioinformatics team and numerous analysis options.
Offer Precision Medicine
Introduce new ways to prevent, diagnose, and treat disease on a personalized level.
Technologies Used for Whole-Genome Sequencing
Low-Pass Sequencing 
Best for
WGS at a lower sequencing depth, typically targeting 0.5-1X coverage of the genome; used in genome-wide association studies (GWAS), high-throughput population screening methods, and polygenic risk score calculation
Benefits
Simplified library preparation and reduced sequencing depth for reduced costs and a high-level, genome-wide screen
Clinical Whole-Genome Sequencing
Best for
CLIA-certified, CAP-accredited assay validated to provide human genome-wide sequencing data for use with clinical samples
Benefits
High-quality library preparation with or without amplification, a 30X mean depth of coverage, and clinically relevant, annotated gene reports
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Why Our Clients Choose Psomagen
Superior Data Quality
Exceeds manufacturer benchmarks
Fast Turnaround
Starting at one week for sequencing projects
US-Based Processing
Sequencing and customer support in Rockville, MD
Ph.D. Level Support
Expert assistance every step of the way, with real-time project updates through our online system
Automated Workflows
Increase scalability and improve reproducibility
CLIA-Certified, CAP-Accredited Labs
Clinical research options available (inquire for more information)
Complete Sequencing Solutions
From extraction to data analysis, with many sample types accepted
Quotes From Our Clients
Being able to generate my own libraries and submit them as a single pool without having to pay for individual sample QC (just 1 QC for the pool I create), let us go from sequencing dozens of samples to 100s of samples and still save $1,000s compared to on campus facilities. That we get the results back faster than we do for on campus work is just icing on the cake.
Zhijun Duan
University of Washington
The NGS services in Psomagen Inc are high-quality, cost-effective and often with quick turn-around-time! People in Psomagen are also very responsive!
Ken Mills
Holy Cross
WGS in Action
WGS Is Only the Beginning
While WGS is the most comprehensive approach, you may have cost concerns or a very specific question. Ask about our full list of other NGS methods and get exactly what you need.
