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Discovering Drug Resistance Using DNA Sequencing

What is Drug Resistance? The World Health Organization (WHO) defines drug resistance (also called antimicrobial resistance) as the change that occurs in microorganisms that renders medications ineffective. There are other types of drug resistance, such as cancer cell resistance to chemotherapeutic agents. This discussion, however, will focus on antimicrobial drug resistance. As antimicrobial drugs become […]

Macrogen and Silicon Biosystems Menarini to Co-Develop CLIA-Certified Genomic Cancer Assays

Collaboration Aims to Integrate Digital Sorting with Next Generation Sequencing (NGS) of Formalin-Fixed Paraffin-Embedded Biopsies and Fine-Needle Aspiration Samples SAN DIEGO and SEOUL, South Korea, Feb. 12, 2016 /PRNewswire/ — Silicon Biosys­tems Menarini and Macrogen, Inc. today announced they will form a partnership to provide clinical assays and innovative procedures for precision medicine in cancer. […]

DNA Sequencing: The Backbone of Personalized Medicine

Concept of Personalized Medical Care As a society, we have been accustomed to the concept of a “one-size-fits-all” approach to healthcare. However, this has not been ideal for many people and limits the success of medical management. There are instances where there is some level of tailoring to the individual, but not to the extent […]

Next-Generation Sequencing Revolutionizes Drug Discovery and Development

Next-Generation Sequencing (NGS) Overview Next-generation sequencing is a massive parallel sequencing technology. Genomic DNA is extracted, fragmented, and linked to adapters and primers for the amplification reaction (PCR) to generate a library. DNA fragments in the library are simultaneously sequenced. This provides a massive set of sequence data in a matter of days. The data […]

Role of Next-Generation Sequencing in Cancer Diagnostics

The significant global burden of cancer has led to increased efforts to determine prevention strategies, early detection, and successful management of patients diagnosed with cancer. The latest data provided by the World Health Organization reveal cancer has accounted for 8.2 million deaths as of 2012¹. Early detection and successful treatment are considered important factors in […]