Epigenomics

Examine the impact of epigenomic modifications that cause diseases and disorders in plants, animals, and humans.

What Is Epigenomics?

Epigenomics is the study of epigenetic changes — such as chromatin assembly, histone modification, and DNA-protein interaction — in a cell.

These modifications are different between different cell types and can affect gene translation and gene expression without changing the DNA sequence.

Why Is Studying Epigenomics Important?

Genetic disorders, metabolic disorders, cancers, degenerative diseases, and changes in plant plasticity have all been linked to epigenetic errors.

Studying the locations and understanding how reversible compound interactions influence genome expression can help scientists recognize the mechanisms by which genes are turned on or off in a disease.

What Can You Do?

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Interrogate Disease

Build a comprehensive epigenetic analysis to identify new biomarkers and therapeutic targets.

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Identify Modifiers

Understand the role heritability, environment, and behavior play in gene expression and cell differentiation.

Epigenomics Tools

Whole Genome Bisulfite Sequencing (WGBS)

Best for:
Profiling genome-wide methylation of DNA that represses transcription and gene expression

Benefits:
Methylated cytosine bases are protected and resulting DNA can be sequenced using various methods
Reduced Representation Bisulfite Sequencing (RRBS)

Best for:
Profiling genome-wide methylation on a single nucleotide scale using a restriction enzyme digestion at CpG sites

Benefits:
Enriched for regions of high methylation, resulting in a greater resolution of the regions of interest
Chromatin Immunoprecipitation Sequencing (ChIP-Seq)

Best for:
Identifying genome-wide binding sites of DNA-associated proteins such as transcription factors or histone modifications

Benefits:
Identifying DNA-binding protein interactions across the entire genome, and understanding the regulation of biological processes in the context of disease
Assay for Transposase Accessible Chromatin Sequencing (ATAC-Seq)

Best for:
Mapping genome-wide chromatin accessibility by detecting open chromatin regions

Benefits:
Provides detailed insight regarding what areas of the DNA are available for interaction with transcriptional factors that play a role in gene expression regulation
Custom Methylation Sequencing

Best for:
Assessing methylation patterns using commercially available or custom hybrid capture approaches

Benefits:
Focus on the scientist's regions of interest which will require less sequencing depth
Small RNA Sequencing

Best for:
Targeting and isolating fewer than 200 nucleotides of small, non-coding RNA known to regulate transcription

Benefits:
Provides detailed insight regarding what areas of DNA are available for interaction with transcriptional factors that play a role in gene expression regulation

Why Psomagen?

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Superior Data Quality

Exceeds manufcturer benchmarks

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Fast Turnaround

Starting at one week for sequencing projects

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US-Based Processing

Sequencing and customer support in Rockville, MD

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Ph.D. Level Support

Expert assistance every step of the way, with real-time project updates through our online system

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Automated Workflows

Increase scalability and improve reproducibility

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CLIA-Certified, CAP-Accredited Labs

linical researCch options available (inquire for more information)

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Complete Sequencing Solutions

From extraction to data analysis, with many sample types accepted

We're Ready for Your Order!

Here's what to expect in your project's life cycle. If you have a question during sequencing, it's easy to get in touch!

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1. Request a Consultation

Create an account through our client portal and get in touch with your local field team and start designing a project. We’ll help drive your research forward with the right tools for your research needs.

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2. Place an Order

After finalizing the scope of work, an official quote will be issued for signing. Then, your sales representative will send specific shipping instructions.

Once all the samples and necessary documents are ready, we can start your project. Need more analysis? Reach out to our bioinformatics experts to dig deeper.

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3. QC and Data Report

All Psomagen sequencing projects come with a built-in QC step to ensure you get the information you need. An account manager will update you on your project's progress in a timely manner.

You can also see some project information and securely view all valid reports on the client portal site.